In vitro characterization and cellular uptake profiles of TAMs-targeted lipid calcium carbonate nanoparticles for cancer immunotherapy
نویسندگان
چکیده
Tumor-associated macrophages (TAMs) are key contributors to tumor development, accelerated invasion and metastasis, induction of immunosuppression. Targeted delivery immunomodulatory agents promote polarization TAMs may alleviate the immunosuppressive microenvironment. Calcium carbonate nanoparticles (CCN), which exhibit excellent biocompatibility, pH sensitivity, easy surface modification, have attracted substantial attention in targeted nano delivery. In this study, CCN were used as a matrix material develop UNO-peptide-modified lipid for immunomodulation by using mannose receptor overexpressed on surfaces targets. The preparation was optimized through single-factor testing with gas diffusion method particle size index. modification phospholipids performed, its targeting effect investigated. average 144.5 ± 3.8 nm 167.0 1.3 nm, respectively. entered via actively uptake mediated receptors. Our results demonstrated that developed controlled nano-size TAMs-targeting properties is highly promising nanocarrier TAM agents.
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ژورنال
عنوان ژورنال: Acta Materia Medica
سال: 2022
ISSN: ['2737-7946']
DOI: https://doi.org/10.15212/amm-2022-0030